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" Enjoy science. Respect your colleagues and laboratory animals. "

Yichang Jia

 Assistant Professor

School of Medicine, Tsinghua University, Beijing, China

Principal Investigator

Peking-Tsinghua Joint Center of Life Sciences, Beijing, China

Office Phone: 86-10-62781045

Email:  yichangjia@mail.tsinghua.edu.cn

Education:

July, 2006        Ph. D. Neuroscience, Institute of Neuroscience, Shanghai Institute for Biological Science, Chinese Academy of Sciences (CAS), Shanghai, China

July, 2001         M.S. Medicine, Nanjing Medical University, Nanjing, Jiangsu, China

Research Experience:

2013-present     Assistant Professor
Department of Basic Medical Sciences, The School of Medicine, Tsinghua University, Beijing, China
Principal Investigator
Peking-Tsinghua Joint Center of Life Sciences, Beijing, China

2007-2012        Howard Hughes Medical Institute Research Associate
Postdoctoral Research Fellow
Howard Hughes Medical Institute
The Jackson Laboratory, Bar Harbor, ME
Laboratory of Susan L. Ackerman
Molecular Basis of Neurodegeneration in the Adult Central Nervous System

2001-2006        Ph. D. Student
Laboratory of Yizheng Wang
Institute of Neuroscience, Shanghai Institute for Biological Science, CAS, Shanghai, China
Functions of TRPC Channels in Neuron Axon Guidance and Survival

1998-2001        Master Student
Nanjing Medical University, China
Effects of Aluminum Chloride on Neuronal Viability and Learning and Memory

Teaching Experience:

2013                  Mentored Liang Guo, Chao Huang, Fangfang Chen, The School of Medicine, Tsinghua University, China

2011                  Mentored Hagit Benyamini, Summer Student, Summer Student Program, The Jackson Laboratory, Bar Harbor, Maine

2009                  Mentored Matthew Younger, Summer Student, Summer Student Program, The Jackson Laboratory, Bar Harbor, Maine

2008                  Assisted Jill Recla, Rotation Student, Graduate School of Biomedical Sciences, University of Maine at The Jackson Laboratory, Bar Harbor, Maine

2001-2006        Assisted and mentored Ph. D. students Jian Zhou, Xia Ding, Shenglian Yang, Wanlu Du, Qiaoyun Yang, Zhenghua Wang, and Qi Chao, Laboratory of Yizheng Wang, Institute of Neuroscience, Shanghai Institute for Biological Science, Chinese Academy of Sciences, Shanghai, China

Awards:

2013                  Janssen Investigator Award

2012                  First place (participant), Award of Shanghai Natural Sciences, 2012, Shanghai, China (2012年度上海市自然科学奖一等奖)

2012                  Selection as “Junior 1000 Talents”, China (中组部第四批青年千人计划)

2012                  NIH Pathway to Independence Award (K99/R00), Mechanisms underlying neurodegeneration caused by dysfunction of pre-mRNA splicing.

2011                  First place, poster contest, postdoctoral retreat, The Jackson Laboratory, Bar Harbor, Maine

2007                  Excellent achievement, Ph. D. Thesis of Shanghai, China

2007                  Excellent Ph. D. Thesis, Chinese Academy of Sciences

2006                  Excellent Graduate Student, Shanghai Institute for Biological Science, China

2005-2006        Excellent Student, Shanghai Institute for Biological Science, China

2005                  First author work ‘Essential role of TRPC channels in the guidance of nerve growth cones by brain-derived neurotrophic factor’ was selected as 10 Major News of China Medical Technology (Annual Selection sponsored by Ministry of Health, P.R.China; Ministry of Science and Technology, P.R.China; State Food and Drug Administration, P.R.China; State Administration of Traditional Chinese Medicine, P.R.China; China Association for Science and Technology; Chinese Medical Association)

2005                  Excellent Scholarship in honor of Head of Chinese Academy of Sciences

2000                  First-class Award of Master Thesis, Nanjing Medical University, China

Publications:

  • Yichang Jia, John Mu, Susan Ackerman. (2012) Mutation of a U2 snRNA Gene Causes Global Disruption of Alternative Splicing and Neurodegeneration. Cell. 148, 296-308.
  • Jian Zhou, Wanlu Du, Kechun Zhou, Yilin Tai, Hanlan Yao, Yichang Jia, Yuqiang Ding, Yizheng Wang. (2008) Critical role of TRPC6 channels in the formation of excitatory synapses. Nat Neurosci. 11, 741-3.
  • YiqunYao, Xia Ding, Yichang Jia, Chuanxin Huang, Yizheng Wang, and Yunhui Xu. (2008) Anti-tumor effect of b-elemene in glioblastoma cells 3 depends on p38 MAPK activation. Cancer Lett. 264, 127-134.
  • Zenghua Wang, Bin Shen, Haolan Yao, Yichang Jia, Jing Ren, Youji Feng and Yizheng Wang. (2007) Blockage of intermediate-conductance-Ca2+-activated K+ channels inhibits progression of human endometrial cancer. Oncogene. 26, 5107-5114.
  • Chuanxin Huang, Yichang Jia, Shenglian Yang, Biao Chen, Hongwei Sun, Feng Shen and Yizheng Wang. (2007) Characterization of ZNF23, a KRAB-containing protein that is downregulated in human cancers and inhibits cell cycle progression. Exp. Cell Res. 313, 254-263.
  • Yichang Jia*, Jian Zhou*, Yilin Tai and Yizheng Wang. (2007) TRPC channels promote cerebellar granule neuron survival. Nature Neuroscience 10, 559-567. * These authors contributed equally to this work. (also see News and Views, Nature Neuroscience 10, 537-538)
  • Yan Li*, Yichang Jia*, Kai Cui*, Ning Li, Zai-Yu Zheng, Yi-Zheng Wang and Xiao-Bing Yuan. (2005) Essential role of TRPC channels in the guidance of nerve growth cones by brain-derived neurotrophic factor. Nature. 434, 894-898. * These authors contributed equally to this work. (also see News and Views, Nature 434, 835-838)
  • Yichang Jia, Caiyun Zhong, and Yingming Wang. (2002) Lipid peroxidation and glutamine synthetase activity in hippocampus of aluminum-induced rat dementia model. Zhonghua laonian yixue zazhi [Chinese Journal of Geriatrics] 2.
  • Yichang Jia, Caiyun Zhong, and Yingming Wang. (2001) Effects of aluminum on amino acid neurotransmitters in hippocampus of rats. Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] 35, 397-400.

Meetings and Conferences:

2013                  Invited Talk, Disease mechanisms underlying neurodegeneration caused by RNA metabolism abnormalities. McGovern Institute Fall Symposium, Boston, USA.

2013                  Invited Talk, Using mouse forward genetics to study disease mechanisms underlying neurodegeneration. BIT’s 3rd Annual World Congress of Molecular & Cell Biology (CMCB-2013), Suzhou, China.

2011                  Poster, Global disruption of alternative splicing and neurodegeneration is caused by mutation of a U2 snRNA gene. Yichang Jia, John Mu, and Susan Ackerman. Eukaryotic mRNA processing, Cold Spring Harbor Laboratory.

2011                  Short Talk, Global disruption of alternative splicing and neurodegeneration is caused by mutation of a U2 snRNA gene. Yichang Jia, John Mu, and Susan Ackerman. The Maine Neuroscience Conference, Bates College, Lewiston, ME.

2010                  Invited Talk, Dysfunction of a basal spliceosomal component results in neurodegeneration. Yichang Jia, John Mu, and Susan Ackerman. JAX-MDIBL Scientific Symposium, The Mount Desert Island Biological Laboratory, Bar Harbor, ME.

2010                  Poster, Mutation of a U2 small nuclear RNA gene results in abnormal alternative splicing and neurodegeneration. Yichang Jia, Jill Recla, and Susan Ackerman. Gordon Research Conference, Post-Transcriptional Gene Regulation, The Biology Of, Newport, RI.

2009                  Poster, A deletion in one of the U2 small nuclear RNA genes causes neurodegeneration. Yichang Jia, Jill Recla, and Susan Ackerman. HHMI Scientific Meeting, Neurobiology: From Cells to Systems, Janelia Farm Research Campus.

2009                  Short Talk, A deletion in one of the U2 small nuclear RNA genes causes neurodegeneration. Yichang Jia, Jill Recla, and Susan Ackerman. Eukaryotic mRNA processing, Cold Spring Harbor Laboratory.

2006                  Short Talk, TRPC channels promote cerebellar granular neuron survival. Yichang Jia, Jian Zhou, Yilin Tai, and Yizheng Wang. Gordon Research Conference, Molecular and Cellular Neurobiology, Hong Kong, PRC.

Research Support:

2013                 Principal Investigator, 国家自然科学基金面上项目, Study disease mechanisms underlying neurodegeneration caused by RNA metabolism abnormalities

2012                 Principal Investigator, Junior 1000 Talents Program

2012                 Principal Investigator, NIH Pathway to Independence Award (K99/R00), Mechanisms Underlying Neurodegeneration Caused by Dysfunction of Pre-mRNA Splicing

Patent:

2007                 The Application of TRPC in Screening Anti-Tumor Medicaments and the Pharmaceutical Use of its Inhibitor. Publication Number:  WO/2007/041965